View source for Publications:Compression, adaptation and efferent control in a revised outer hair cell functional model

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{{PublicationSetupTemplate|Author=Antanas Stasiunas, Antanas Verikas, Marija Bacauskiene, Rimvydas Miliauskas, Natalija Stasiuniene, Kerstin Malmqvist
|PID=237436
|Name=Stasiunas, Antanas (Department of Applied Electronics, Kaunas University of Technology, LT-3031 Kaunas, Lithuania);Verikas, Antanas [av] (Högskolan i Halmstad [2804], Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE) [3905], Halmstad Embedded and Intelligent Systems Research (EIS) [3938]);Bacauskiene, Marija (Department of Applied Electronics, Kaunas University of Technology, LT-3031 Kaunas, Lithuania);Miliauskas, Rimvydas (Department of Physiology, Kaunas University of Medicine, LT-3000 Kaunas, Lithuania);Stasiuniene, Natalija (Department of Biochemistry, Kaunas University of Medicine, LT-3000 Kaunas, Lithuania);Malmqvist, Kerstin [kermalx] (Högskolan i Halmstad [2804], Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE) [3905], Halmstad Embedded and Intelligent Systems Research (EIS) [3938], Intelligenta system (IS-lab) [3941])
|Title=Compression, adaptation and efferent control in a revised outer hair cell functional model
|PublicationType=Journal Paper
|ContentType=Refereegranskat
|Language=eng
|Journal=Medical Engineering and Physics
|JournalISSN=1350-4533
|Status=published
|Volume=27
|Issue=9
|HostPublication=
|Conference=
|StartPage=780
|EndPage=789
|Year=2005
|Edition=
|Pages=
|City=Amsterdam
|Publisher=Elsevier
|Series=
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|DOI=http://dx.doi.org/10.1016/j.medengphy.2005.03.002
|ISI=000232377700007
|PMID=16171738
|ScopusId=2-s2.0-24944546619
|NBN=urn:nbn:se:hh:diva-257
|LocalId=2082/552
|ArchiveNumber=
|Keywords=Cochlea;Outer hair cell;Mechanomotility;Motor protein prestin;Efferent synapse
|Categories=Medicinsk bioteknologi (304)
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|Abstract=<p>In the cochlea of the inner ear, outer hair cells (OHC) together with the local passive structures of the tectorial and basilar membranes comprise non-linear resonance circuits with the local and central (afferent–efferent) feedback. The characteristics of these circuits and their control possibilities depend on the mechanomotility of the OHC. The main element of our functional model of the OHC is the mechanomotility circuit with the general transfer characteristic y = k tanh(x − a). The parameter k of this characteristic reflects the axial stiffness of the OHC, and the parameter a working position of the hair bundle. The efferent synaptic signals act on the parameter k directly and on the parameter a indirectly through changes in the membrane potential. The dependences of the sensitivity and selectivity on changes in the parameters a and k are obtained by the computer simulation. Functioning of the model at low-level input signals is linear. Due to the non-linearity of the transfer characteristic of the mechanomotility circuit the high-level signals are compressed. For the adaptation and efferent control, however, the transfer characteristic with respect to the initial operating point should be asymmetrical (a &gt; 0). The asymmetry relies on the deflection of the hair bundle from the axis of the OHC.</p>
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|CreatedDate=2006-11-24
|PublicationDate=2006-11-24
|LastUpdated=2013-01-14
|diva=http://hh.diva-portal.org/smash/record.jsf?searchId=1&pid=diva2:237436}}
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