View source for Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview

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{{PublicationSetupTemplate|Author=Thorsteinn Rögnvaldsson, Liwen You, Daniel Garwicz
|PID=239220
|Name=Rögnvaldsson, Thorsteinn [denni] (Högskolan i Halmstad [2804], Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE) [3905], Halmstad Embedded and Intelligent Systems Research (EIS) [3938]);You, Liwen [liyo] (Högskolan i Halmstad [2804], Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE) [3905]);Garwicz, Daniel (Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska University Hospital, SE-17176, Stockholm, Sweden)
|Title=Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview
|PublicationType=Journal Paper
|ContentType=Refereegranskat
|Language=eng
|Journal=Expert Review of Molecular Diagnostics
|JournalISSN=1473-7159
|Status=published
|Volume=7
|Issue=4
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|StartPage=435
|EndPage=451
|Year=2007
|Edition=
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|Publisher=Expert Reviews Ltd
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|DOI=http://dx.doi.org/10.1586/14737159.7.4.435
|ISI=000248620700010
|PMID=17620050
|ScopusId=2-s2.0-34447517453
|NBN=urn:nbn:se:hh:diva-2002
|LocalId=2082/2397
|ArchiveNumber=
|Keywords=bioinformatics;cleavage rule;HIV;human immunodeficiency virus;physicochemical property;prediction;protease
|Categories=Medicin och hälsovetenskap (3)
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|Abstract=<p>HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict cleavage of novel substrates using bioinformatic analysis methods. This review describes the methods that have been utilized to date to address this important problem and the results achieved. The data sets used are also reviewed and important aspects of these are highlighted.</p>
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|CreatedDate=2008-10-06
|PublicationDate=2008-10-06
|LastUpdated=2013-10-15
|diva=http://hh.diva-portal.org/smash/record.jsf?searchId=1&pid=diva2:239220}}
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